Checkpoint inhibitor-associated immune arthritis
نویسندگان
چکیده
منابع مشابه
Immune Checkpoint Inhibitor Therapy Associated Hypophysitis
Ipilimumab is a monoclonal antibody directed against CTLA4 T-lymphocyte antigen used as cancer therapy. Immune-related adverse events are common side effects and may include hypophysitis-related hypopituitarism. The clinical features of six patients with ipilimumab-induced hypophysitis (IH) are described. The clinical features of IH reported in clinical trials, including the incidence of IH by ...
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OBJECTIVE To report first-hand narrative experience of autoimmune encephalitis and to briefly review currently available evidence of autoimmune encephalitis in cancer patients treated with immune checkpoint inhibitors. SETTING A case study is presented on the management of a patient who developed autoimmune encephalitis during nivolumab monotherapy occurring after 28 weeks on anti-PD-1 monoth...
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Immune checkpoint inhibitors are the mainstay of treatment for advanced melanoma, and their use is being increasingly implicated in the development of autoimmune endocrinopathies. We present a case of a 52-year-old man with metastatic melanoma on combination nivolumab and ipilumimab therapy who developed concurrent hypophysitis, type 1 diabetes mellitus (T1DM) and diabetes insipidus. He present...
متن کاملImmune checkpoint inhibitor-associated interstitial lung diseases: some progress but still many issues
Affiliations: Univ. Paris–Sud, Faculté de Médecine, Le Kremlin Bicêtre, France. AP-HP, Centre de Référence de l’Hypertension Pulmonaire Sévère, Département Hospitalo-Universitaire (DHU) Thorax Innovation (TORINO), Service de Pneumologie, Hôpital de Bicêtre, Le Kremlin Bicêtre, France. UMR_S 999, Univ. Paris– Sud; INSERM; Laboratoire d’Excellence (LabEx) en Recherche sur le Médicament et l’Innov...
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Immune checkpoint inhibitor therapy (ICT) is a new treatment strategy developed for the treatment of cancer. ICT inhibits pathways known to downregulate the innate immune response to cancer cells. These drugs have been shown to be effective in the treatment of a variety of cancers, including metastatic melanoma and lung cancer. Challenges in response evaluation of patients in ICT have risen as ...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2018
ISSN: 0003-4967,1468-2060
DOI: 10.1136/annrheumdis-2018-213470